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| Casulari,L.A.; Dondi,D.; Maggi,R.; Demissie,M.; Piccolella,M.; Piva,F.. |
| Glucocorticoids (Gc) influence the differentiation of neural crest-derived cells such as those composing sympathoadrenal tumors like pheochromocytomas, as well as neuroblastomas and gangliomas. In order to obtain further information on the effects of Gc on cells evolving from the neural crest, we have used the human neuroblastoma cell line SK-N-SH to analyze: 1) the presence and the binding characteristics of Gc receptors in these cells, 2) the effect of dexamethasone (Dex) on the migration of SK-N-SH cells, and 3) the effect of Dex on the organization of the cytoskeleton of SK-N-SH cells. We show that: 1) receptors that bind [³H]-Dex with high affinity and high capacity (Kd of 9.6 nM, Bmax of 47 fmol/mg cytosolic protein, corresponding to 28,303... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human neuroblastoma; SK-N-SH cells; Glucocorticoids; Migration; Cytoskeleton. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900011 |
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| Tatemoto,Patricia; Bernardino,Thiago; Rodrigues,Frederico Augusto Mazzocca Lopes; Zanella,Adroaldo José. |
| ABSTRACT The objective of this study was to evaluate the effects of stereotypic behavior on productivity measures in sows. Frequent expression of stereotypies by pigs has been reported, even when pigs are not maintained in crates. This behavior is only observed in animals kept in captivity and is a wide-range welfare indicator, since it is considered to develop in situations of chronic stress or frustration. When comparing groups of sows showing low or high frequency of stereotypy expression, we found that stereotypic behavior did not affect productivity. Moreover, it did not affect physiological welfare indicators, such as salivary cortisol concentration or glucocorticoids in the placenta. There were no differences in productivity parameters, including... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glucocorticoids; Pigs; Placenta; Stereotypies; Welfare. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982019000100201 |
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| Guimarães-Fernandes,F.; Samano,M.N.; Vieira,R.P.; Carvalho,C.R.; Pazetti,R.; Moreira,L.F.P.; Pêgo-Fernandes,P.M.; Jatene,F.B.. |
| Pneumonectomy is associated with high rates of morbimortality, with postpneumonectomy pulmonary edema being one of the leading causes. An intrinsic inflammatory process following the operation has been considered in its physiopathology. The use of corticosteroids is related to prevention of this edema, but no experimental data are available to support this hypothesis. We evaluated the effect of methylprednisolone on the remaining lungs of rats submitted to left pneumonectomy concerning edema and inflammatory markers. Forty male Wistar rats weighing 300 g underwent left pneumonectomy and were randomized to receive corticosteroids or not. Methylprednisolone at a dose of 10 mg/kg was given before the surgery. After recovery, the animals were sacrificed at 48... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pneumonectomy; Glucocorticoids; Pulmonary edema; Vascular endothelial growth factor; Transforming growth factor beta; Animal model. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700006 |
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| The effect of dexamethasone on ethanol-induced hypothermia was investigated in 3.5-month old male Wistar rats (N = 10 animals per group). The animals were pretreated with dexamethasone (2.0 mg/kg, ip; volume of injection = 1 ml/kg) 15 min before ethanol administration (2.0, 3.0 and 4.0 g/kg, ip; 20% w/v) and the colon temperature was monitored with a digital thermometer 30, 60 and 90 min after ethanol administration. Ethanol treatment produced dose-dependent hypothermia throughout the experiment (-1.84 ± 0.10, -2.79 ± 0.09 and -3.79 ± 0.15oC for 2.0, 3.0 and 4.0 g/kg ethanol, respectively, 30 min after ethanol) but only the effects of 2.0 and 3.0 g/kg ethanol were significantly antagonized (-0.57 ± 0.09 and -1.25 ± 0.10, respectively, 30 min after ethanol)... |
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Palavras-chave: Ethanol; Dexamethasone; Hypothermia; Glucocorticoids; Rats. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100011 |
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| Leal,A.M.O.; Moreira,A.C.. |
| Temporal organization is an important feature of biological systems and its main function is to facilitate adaptation of the organism to the environment. The daily variation of biological variables arises from an internal time-keeping system. The major action of the environment is to synchronize the internal clock to a period of exactly 24 h. The light-dark cycle, food ingestion, barometric pressure, acoustic stimuli, scents and social cues have been mentioned as synchronizers or" zeitgebers". The circadian rhythmicity of plasma corticosteroids has been well characterized in man and in rats and evidence has been accumulated showing daily rhythmicity at every level of the hypothalamic-pituitary-adrenal (HPA) axis. Studies of restricted feeding in rats are... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Feeding; Glucocorticoids; CRH; ACTH; Circadian rhythm. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200003 |
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| Pilipović,I.; Kosec,D.; Radojević,K.; Perišić,M.; Pešić,V.; Stojić-Vukanić,Z.; Leposavi,G.. |
| There is evidence that the major mediators of stress, i.e., catecholamines and glucocorticoids, play an important role in modulating thymopoiesis and consequently immune responses. Furthermore, there are data suggesting that glucocorticoids influence catecholamine action. Therefore, to assess the putative relevance of glucocorticoid-catecholamine interplay in the modulation of thymopoiesis we analyzed thymocyte differentiation/maturation in non-adrenalectomized and andrenalectomized rats subjected to treatment with propranolol (0.4 mg·100 g body weight-1·day-1) for 4 days. The effects of β-adrenoceptor blockade on thymopoiesis in non-adrenalectomized rats differed not only quantitatively but also qualitatively from those in adrenalectomized rats. In... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Catecholamines; Glucocorticoids; Β-adrenoceptors; Propranolol; Thymocyte apoptosis; Thymocyte proliferation; Thymocyte differentiation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300009 |
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| Sadoul, Bastien; Geffroy, Benjamin. |
| Stress in teleosts is an increasingly studied topic because of its interaction with growth, reproduction, immune system and ultimately fitness of the animal. Whether it is for evaluating welfare in aquaculture, adaptive capacities in fish ecology, or to investigate effects of human‐induced rapid environmental change, new experimental methods to describe stress physiology in captive or wild fish have flourished. Cortisol has proven to be a reliable indicator of stress and is considered the major stress hormone. Initially principally measured in blood, cortisol measurement methods are now evolving towards lower invasiveness and to allow repeated measurements over time. We present an overview of recent achievements in the field of cortisol measurement in... |
| Tipo: Text |
Palavras-chave: Aquaculture; Cortisol; Glucocorticoids; Non-invasive; Stress; Welfare. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00478/59001/61616.pdf |
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